1354823-36-1
- Product Name：Remdesivir Intermediate
- Molecular Formula：C21H27N2O7P
- Purity：99%
- Molecular Weight：450.4
Product Details;
CasNo： 1354823-36-1
Molecular Formula： C21H27N2O7P
Factory Supply High Purity Reliable Quality Remdesivir Intermediate 1354823-36-1 Cheap Price
- Molecular Formula:C21H27N2O7P
- Molecular Weight:450.4
Remdesivir Intermediate (Cas 1354823-36-1) Usage
| Description | Remdesivir is an antiviral medicine that works against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). |
|
Uses |
Remdesivir Intermediate is used for the treatment of ebola and emerging viruses. |
1354823-36-1 Relevant articles
Development of a Scalable Lanthanide Halide/Quaternary Ammonium Salt System for the Nucleophilic Addition of Grignard Reagents to Carbonyl Groups and Application to the Synthesis of a Remdesivir Intermediate
Andrew C. Stevens*, Katrien Brak, W. Stacy Bremner, Angela M. Brown, Andrei Chtchemelinine, Lars Heumann*, James A. Kerschen, Witold Subotkowski, Tiago Vieira*, Lydia C. Wolfe, Boran Xu, and Chia-Yun Yu
, Org. Process Res. Dev. 2022, 26, 3, 754–763
This manuscript describes the development and implementation of a scalable additive system, consisting of a lanthanide salt and a solubilizing quaternary ammonium salt, to improve the yield and robustness of the addition of an organomagnesium reagent to a ribonolactone en route to remdesivir. This system was found to be generally applicable in enhancing other challenging organomagnesium additions to enolizable and hindered carbonyl-containing compounds.
Intermolecular interaction among Remdesivir, RNA and RNA-dependent RNA polymerase of SARS-CoV-2 analyzed by fragment molecular orbital calculation
Koichiro Kato a b, Teruki Honma c, Kaori Fukuzawa d e
, Journal of Molecular Graphics and Modelling Volume 100, November 2020, 107695
Remdesivir bound to the terminus of an primer-RNA strand was further stabilized by diagonal π-π stacking with the -1A’ base of the complementary strand and an additional hydrogen bond with an intra-strand base,
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